About BONEcheck



1+ Years
Research

What is BONEcheck?

BONEcheck is a set of algorithms that have been designed to predict the likelihood of fractures and its consequences, assess skeletal age, and ascertain bone loss according to an individual's risk profile. The profile incorporates a variety of factors, such as gender, age, bone mineral density, prior fracture history, fall history, pre-existing medical conditions, and genetic makeup.


Who is BONEcheck for?

BONEcheck is intended for men and women aged 50 years and above. The primary objective of the tool is to empower individuals, men and women, to self-assess their bone health and adopt suitable measures to mitigate their risk of fracture and mortality. The tool is not meant to offer clinical recommendations or make decisions regarding treatment options, as such decisions should be made in consultation with a medical practitioner or a bone specialist.

It is important to acknowledge that BONEcheck cannot predict with certainty whether an individual will sustain a fracture in the future or not. Nevertheless, the tool can provide an informed estimation of the probability of fracture and the potential benefits of treatment.


How BONEcheck is developed?

BONEcheck was created based on data collected from five sources: the Dubbo Osteoporosis Epidemiology Study (researchdata.edu.au/dubbo-osteoporosis-epidemiology-study/96809), the Danish Nationwide Registry, the Study of Osteoporotic Fractures (sofonline.ucsf.edu), The Osteoporotic Fractures in Men Study (mrosonline.ucsf.edu), and the Vietnam Osteoporosis Study (Ho-Pham and Nguyen, Osteoporosis and Sarcopenia 2017).

The Dubbo Osteoporosis Epidemiology Study began in 1989, recruiting over 2500 individuals aged 60 years and older from the Dubbo city and surrounding regions. Since the inception of the original cohort, an additional 1500 men and women, also aged 60 years and older at the time of enrolment, from the Dubbo city have been included in the study. Funding for the study has been provided by the National Health and Medical Research Council, as well as untied educational grants from several sources, including Amgen Australia, Merck Sharp and Dohme, Sanofi-Aventis, Novartis, Bupa Health Foundation, and the Ernest Heine Family Foundation.

The investigators of the Dubbo Osteoporosis Epidemiology Study are:
  • Professor John A. Eisman (Garvan Institute of Medical Research).
  • Professor Tuan V. Nguyen (University of Technology Sydney).
  • Professor Jacqueline R. Center (Garvan Institute of Medical Research).
  • Sr Janet Watters (Garvan Institute of Medical Research).

Behind the BONEcheck

BONEcheck was designed and developed by members of Nguyen's Osteoporosis Research Lab at the University of Technology Sydney (UTS), Australia. The development of BONEcheck was partly supported by a grant from the Australian National Health and Medical Research Council (Grant Number APP1195305) and an Amgen Global Competitive grant awarded to Professor Tuan V. Nguyen.

Meet our developers

Prof Tuan V. Nguyen AM

Distinguished Professor at University of Technology Sydney, Australia

Dr Thach S.Tran

Research fellow at University of Technology Sydney, Australia

Dr Phuong-Thao Ho-Le

Research fellow at University of Technology Sydney, Australia

Prof Steve Frost

University of Wollongong, Australia

Dinh Tan Nguyen

PhD student at University of Technology Sydney, Australia

Liem Pham

CTO at Saigonmec, Vietnam

Tien Dat Hoang

Graduated student at Ha Tinh University, Vietnam

Phuc Vinh Ho-Van

Master student, Charles Darwin University, Australia

Collaboration Team

Dr. Subashini C. Thambiah

Associate Professor
Department of Pathology
Faculty of Medicine and Health Sciences
Universiti Putra Malaysia

Dr. Intan Nureslyna Samsudin

Associate Professor
Department of Pathology
Faculty of Medicine and Health Sciences
Universiti Putra Malaysia

Dr. Lan T. Ho Pham

Pham Ngoc Thach University of Medicine
Co-founder, Saigon Precision Medicine Research Center (Saigonmec), Vietnam

Dr. Patnarin Pongkulkiat

Medical staff
Division of Rheumatolgy
Department of Medicine
Faculty of Medicine
Khon Kaen University

Dr. Eusni Rahayu Mohd. Tohit

Associate Professor
Department of Pathology
Faculty of Medicine and Health Sciences
Universiti Putra Malaysia

Dr. Yeap Swan Sim

President
Malaysian Osteoporosis Society

Dr. Chatlert Pongchaiyakul

Professor
Division of Endocrinology and Metabolism
Department of Medicine
Faculty of Medicine
Khon Kaen University

Dr. Wiphat Kittiweerawong

Department of Medicine
Faculty of Medicine
Khon Kaen University

First official version was released in 15 May 2023

Contact Us

Email

Please email us if have any suggestions or comments

Location

15 Broadway, Ultimo NSW 2007, Australia